Astragalus membranaceus alleviates age-associated endometrial deterioration and restores uterine receptivity

With the increasing prevalence of delayed childbearing, advanced maternal age has emerged as a major challenge to reproductive success. Beyond ovarian aging, accumulating evidence indicates that impaired endometrial function plays a critical and independent role in implantation failure in older women. However, effective non-hormonal strategies to improve age-associated endometrial decline remain limited. Here, we report that Astragalus membranaceus, a traditional Chinese medicinal herb, markedly ameliorates age-associated endometrial deterioration and restores uterine receptivity in aged mice. Astragalus treatment significantly alleviated senescence-related phenotypes, improved endometrial structural integrity, and restored the expression of key receptivity-associated markers. Functional assessment further demonstrated improved implantation outcomes following Astragalus intervention. These findings identify Astragalus membranaceus as a potential non-hormonal therapeutic candidate for alleviating endometrial aging and improving reproductive outcomes in women of advanced maternal age.